Super-enhancer - Wikipedia
A super-enhancer, illustrated in the lower panel of the Figure, is a region of the mammalian genome comprising multiple typical enhancers that is collectively bound by an array of …
Super-Enhancers in the Regulation of Gene Transcription: …
Super-enhancers (genome elements that activate gene transcription) are DNA regions with an elevated concentration of transcriptional complexes. These multiprotein structures contain, …
Current progress and future perspective of super-enhancers
Jul 2, 2025 · Super-enhancers are a super-cluster of enhancers formed by serially arranged regulatory elements that can strongly drive the expression of cell-related genes. Hundreds of …
What are super-enhancers? - Nature Genetics
Dec 30, 2014 · Here we review the identification and composition of super-enhancers, describe links between super-enhancers, gene regulation and disease, and discuss the functional …
Super-enhancers: drivers of cells’ identities and cells’ debacles
Clusters of enhancers, called super-enhancers, are more densely occupied by transcriptional activators than enhancers, driving stronger expression of their target genes, which have …
Super-Enhancers and Their Parts: From Prediction Efforts to
Mar 7, 2024 · Here, we study and summarise the classification of super-enhancer constituents, their possible modes of interaction, and cross-regulation, including super-enhancer RNAs …
Superenhancers as master gene regulators and novel therapeutic …
Feb 1, 2023 · Superenhancers (SEs), identified as novel epigenetic regulatory elements, are clusters of enhancers with cell-type specificity that can drive the aberrant transcription of …
Super-Enhancers in the Control of Cell Identity and Disease
Super-enhancers are large clusters of transcriptional enhancers that drive expression of genes that define cell identity.
Super-enhancers in tumors: unraveling recent advances in their …
Jan 21, 2025 · Super enhancers are a unique class of enhancers that possess a distinct structure and mechanism, which enable them to exhibit stronger gene transcription regulatory function …
Super-enhancers include classical enhancers and facilitators to …
Super-enhancers are compound regulatory elements that control expression of key cell identity genes. They recruit high levels of tissue-specific transcription factors and co-activators such as …