These parts of the selectin molecules are responsible for their targeting to different compartments: P-selectin to secretory granules, E-selectin to the plasma membrane, and L-selectin to the tips of …

Aug 2, 2025 · P-selectin is found on both platelets and endothelial cells, becoming rapidly available on the cell surface upon activation. These distinct cellular locations reflect their specialized roles in …

This review summarizes selectin biology and pathology, structure and ligand binding, and selectin antagonists that have reached clinical testing with an emphasis on E-selectin.

L-selectin, which is found on leukocytes, was the first discovered, by virtue of an interesting phenomenon called lymphocyte homing, in which lymphocytes were removed from various …

Apr 20, 2025 · The selectin family consists of three main types: E-selectin (expressed on endothelial cells), P-selectin (found on platelets and endothelial cells), and L-selectin (present on leukocytes). …

Three selectins (P-selectin, E-selectin, and L-selectin) have been identified, each differing in their patterns of expression and regulation.

Jul 19, 2023 · Three type-I-cell surface glycoproteins make up the selectin family, namely L-selectin, P-selectin and E-selectin.

The human L-selectin gene (sell) is located on the long arm of chromosome 1 (1q24.2), and is arranged in tandem with its family members (in the order: L-, P-, and E-selectin).

May 14, 2019 · L-selectin (CD62L) is a type-I transmembrane glycoprotein and cell adhesion molecule that is expressed on most circulating leukocytes. Since its identification in 1983, L-selectin has been …

Nov 30, 2023 · Members of the selectin family, E-selectin (endothelial), L-selectin (leukocyte) and P-selectin (platelet), all of which bind to fucosylated carbohydrates [1]. For example P-selectin on …