Understanding human gene function in living organisms has long been hampered by fundamental differences between species.

Respiratory infections are among the leading causes of illness and death in the elderly, driven by immune aging, chronic ...

Using CRISPR-based technologies, the MoDeL team introduces precise genetic modifications in mice, enabling researchers to uncover how mammalian genes maintain health and contribute to disease.

In the development of Parkinson’s disease, it may not be a good idea to turn the amp to 11. High-volume noise exposure produced motor deficits in a mouse model of early-stage Parkinson’s disease, and ...

Spinal deformities such as scoliosis and kyphosis are among the most serious complications of neurofibromatosis type 1 (NF1), a genetic disorder that affects about one in 3,000 people.

A new study has discovered in mouse models that genes associated with repairing mismatched DNA are critical in eliciting damages to neurons that are most vulnerable in Huntington's disease and ...

Pancreatic cancer is a rare disease; however, its initially inconspicuous symptoms and aggressive nature make it one of the deadliest forms of cancer.

Myotonic dystrophy type 1 (DM1) is the most common form of adult-onset muscular dystrophy, affecting about 1 in 8,000 people. While it is well known for causing muscle weakness and stiffness, DM1 also ...