Abnormal microglial energy metabolism in AD. Translocation of Aβ into microglial mitochondria by the outer membrane translocase (TOM) impairs mitochondrial function and inhibits phagocytosis. TREM2 ...
“Most people probably think that inflammation in the brain is something bad and that you should inhibit the inflammatory system in case of illness. But inflammation doesn’t just have to be negative,” ...
Alzheimer's disease (AD) is a highly debilitating neurodegenerative disease characterized by the progressive loss of memory and decline of mental functions. Earlier research has uncovered some of the ...
A clearance mechanism involving microglia has been known to relieve neurons of toxic protein aggregates such as those associated with Alzheimer’s disease and Parkinson’s disease. Unfortunately, this ...
New research has identified that neuroinflammation driven by microglia (immune cells in the brain) is a primary underlying ...
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Brain immune cells drive persistent negative emotions after repeated binge drinking
New research has identified that neuroinflammation driven by microglia (immune cells in the brain) is a primary underlying ...
Risk assessment is complicated, and not the same for all groups. Participants in the Dominantly Inherited Alzheimer Network carry AD mutations that spur massive plaque deposition and lead to memory ...
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