Altered intestinal barrier function is postulated to be a central predisposing factor to intestinal diseases, including inflammatory bowel diseases and food allergies. However, the mechanisms involved ...

Eosinophils and mast cells are two types of immune cells with critical roles in responding to foreign assaults. When these cells do not function properly, several disease outcomes can develop (e.g.

Mast cells are pivotal effectors in immune responses, acting as both sentinels and mediators in allergic and inflammatory processes. Their ability to rapidly degranulate and release a myriad of ...

What Is Advanced Systemic Mastocytosis? Mast cells, found in connective tissue throughout the body, are a type of white blood cell that helps the immune system function properly and protect against ...

Third in a series of articles on COVID-19 and its effects on the gut, this article will explore “Long COVID” (also called “post-acute COVID syndrome”) and the role mast cells play in producing gut ...

Barzolvolimab achieved sustained complete responses and improved quality of life in patients with CSU up to 76 weeks post-treatment. The therapy targets mast cells by inhibiting receptor tyrosine ...

Allakos is a clinical stage biotechnology company developing therapeutics which target immunomodulatory receptors present on immune effector cells involved in allergy, inflammatory and proliferative ...