In its effort to correlate genomic structure with gene function, the 4D Nucleome Consortium (4DN), led by Job Dekker, Ph.D., ...

The genome is more than a linear code; it is a dynamic structure whose three-dimensional folding dictates how genes are regulated. Traditional sequencing technologies capture base-level variation but ...

Engineers at the University of California have developed a new data structure and compression technique that enables the ...

A research team at The University of Osaka revealed that the loss of heterochromatin can cause a chain reaction leading to ...

Gene regulation and chromatin dynamics constitute central themes in modern molecular biology, governing how the genetic blueprint is accessed and utilised during development, differentiation and ...

Left: Imaging of lamin A/C structures in a physically expanded nucleus from an individual with progeria. Right: Same, but with 3D genomic reads overlaid in their original spatial locations, colored by ...

New work from UC Davis and the University of Utah shows how the 3D structure of DNA inside a germ cell commits it to develop into a sperm cell. The discovery could improve understanding of fertility ...

Genomic analysis across 14 psychiatric disorders reveals extensive shared genetic architecture, challenging diagnostic ...

Before cells can divide by mitosis, they first need to replicate all of their chromosomes, so that each of the daughter cells can receive a full set of genetic material. Scientists have until now ...

Life in the wild is never constant; animals adapt quickly if they are to survive. Climate change, the reduction of habitats, ...

A large-scale population genomic study has shed new light on the evolutionary and domestication history of the button ...