Figure 1: Formins are required for the integrity of actin cables. We found that a loss of formins in budding yeast resulted in a rapid and reversible loss of actin cables. After the inactivation of ...

Researchers have visualized at the molecular level how formins bind to the ends of actin filaments. This allowed them to uncover how formins mediate the addition of new actin molecules to a growing ...

Formins promote the assembly of actin filaments in the cytoplasm. This leads to the release of MAL (megakaryocytic acute leukaemia; also known as MRTF) from monomeric G-actin and the accumulation of ...

This is a preview. Log in through your library . Abstract Formins are large multidomain proteins required for assembly of actin cables that contribute to the polarity and division of animal and fungal ...

Every cell in the human body contains a complex system to transport essential cargoes such as proteins and membrane vesicles, from point A to point B. These tiny molecular motor proteins move at ...

Actin is a highly abundant protein that controls the shape and movement of all our cells. Actin achieves this by assembling into filaments, one actin molecule at a time. There are as many as 15 ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, No. 12 (Jun. 15, 1993), pp. 5554-5558 (5 pages) Mutations at the mouse limb deformity (ld) locus result in ...

Formins are made of two identical parts (red, orange) that encircle the actin (grey) filament in a ring-like conformation. “Our discovery allows us to interpret decades of biochemical studies on ...

Nine years ago, Goode and his colleagues discovered that a family of proteins called formins stimulate the rapid growth of actin filaments. Recently, the team began to question how a cell controls the ...