Methotrexate, a folate antagonist that blocks folic acid activity, is the most widely used disease-modifying antirheumatic drug for rheumatoid arthritis. It enters the cell via several pathways, one ...

For decades, methotrexate has formed the foundation of therapy in RA, either alone or in combination with other drugs; however, its mechanisms of action remain poorly understood, and many patients ...

Megaloblastosis appeared in a patient receiving pyrimethamine. Pyrimethamine seemed to act as does the folate antagonist methotrexate in short-term in vitro culture of the patient's bone marrow. It ...

Several different causes of aging have been discovered, but the question remains whether there are common underlying mechanisms that determine aging and lifespan. Researchers from the Max Planck ...

A comprehensive panel of mutation scanning assays detects mutations in the APC, TP53, KRAS, BRAF genes and hypermethylated APC and MLH1 DNA in plasma of patients with various stages of colorectal ...

Just when you thought you had your vitamins figured out, science throws us a curveball. New research from Texas A&M University is challenging everything we thought we knew about folate (that’s vitamin ...

Researchers have linked several single nucleotide polymorphisms in the DNA of Puerto Rican adults to altered concentrations of blood homocysteine and folate and the content of uracil in blood DNA.