Serum complement proteins comprise an important system that is responsible for several innate and adaptive immune defence mechanisms. There were three well-described pathways known to lead to the ...

Innate Immunity is a nonspecific host defense mechanism against foreign antigens. It is the first line of defense in a host and occurs immediately or within hours after exposure. This type of immunity ...

The innate immune protein C1q seems to have a thing for neurons. Already implicated in synaptic pruning by microglia, now it is reported to also slow down protein production in neurons of the aging ...

In the last five years, neuronal pentraxins have emerged as potential markers of synaptic loss. In the case of NPTX2, researchers may now be able to explain why. In the March 29 Science Translational ...

After mild traumatic brain injury (TBI), a molecule called complement factor C1q may play a role in the secondary effects of brain injury, such as sleep disruption, epileptic activity, and ...

Anti-C1q antibodies are a promising marker for the diagnosis and management of lupus nephritis. Immunological tests can differentiate proliferative from non-proliferative lupus nephritis, but anti-C1q ...

Complement component 3, often called C3, is an essential protein of the immune system. This protein plays a vital role in the body’s innate immune system, providing: the first line of defense against ...

A study conducted at the lab of Beth Stevens, Ph.D., at Boston Children's Hospital, has revealed that an immune protein impacts neuronal protein synthesis in the aging brain. Previous work from the ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 117, No. 37 (September 15, 2020), pp. 22992-23000 (9 pages) Antibodies may bind to bacterial pathogens or their ...

The last time I spoke about Annexon Inc. (ANNX) it was with respect to a Seeking Alpha article entitled "Annexon: With IGOS Study Completion, Pre-BLA Meeting In 1st Half 2025 On Deck". With respect to ...